Capillary

Blood flows from the heart to arteries, which branch and narrow into arterioles, and then narrow further still into capillaries. After the tissue has been perfused, capillaries branch and widen to become venules and then widen more and connect to become veins, which return blood to the heart.

Capillaries (pronounced /ˈkæpɨlɛri/) are the smallest of a body's blood vessels and are part of the microcirculation. They are only 1 cell thick. These microvessels, measuring 5-10 μm in diameter, connect arterioles and venules, and enable the exchange of water, oxygen, carbon dioxide, and many other nutrient and waste chemical substances between blood and surrounding tissues.^[1]

1 Anatomy
- 1.1 Types
2 Physiology
3 The variables
4 History
5 See also
6 References
7 External links

Anatomy

Blood flows from the heart to the arteries, which branch and narrow into the arterioles, and then branch further still into the capillaries. After the tissue has been perfused, capillaries join and widen to become venules and then widen more to become veins, which return blood to the heart.

Capillaries do not function on their own. The "capillary bed" is an interweaving network of capillaries supplying an organ. The more metabolically active the cells, the more capillaries they will require to supply nutrients and carry away waste products.

A capillary bed can consist of two types of vessels: true capillaries which branch mainly from metarterioles and provide exchange between cells and the circulation. Secondly, capillary beds also consists of a vascular shunt which is a short vessel that directly connects the arteriole and venule at opposite ends of the bed.

Metarterioles provide direct communication between arterioles and venules and are important in bypassing the bloodflow through the capillaries. The internal diameter of 8 μm forces the red blood cells to partially fold into bullet-like shapes and to go into single file in order for them to pass through.

Precapillary sphincters are rings of smooth muscles at the origin of true capillaries that regulate blood flow into true capillaries and thus control blood flow through a tissue.

Types

There are three types of capillaries:

Continuous - They are continuous in the sense that the endothelial cells provide an uninterrupted lining, and only allow small molecules, like water and ions to diffuse through tight junctions which leave gaps of unjoined membrane which are called intercellular clefts. Tight junctions can be further divided into two subtypes:

Those with numerous transport vesicles that are primarily found in skeletal muscles, lungs, gonads, and skin.
Those with few vesicles that are primarily found in the central nervous system. These capillaries are a constituent of the blood-brain-barrier.

Fenestrated - Fenestrated capillaries (derived from "fenestra," Latin for "window") have pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules ^[2]^[3] and limited amounts of protein to diffuse. In the renal glomerulus there are larger fenestrae which have no diaphragms (although there are pedicels (podocyte foot processes) that have slit pores with an analogous function to the diaphragm of the capillaries). Both types of fenestrated blood vessels have continuous basal lamina and are primarily located in the endocrine glands, intestines, pancreas, and glomeruli of kidney.
Sinusoidal - Sinusoidal or discontinuous capillaries are special fenestrated capillaries that have larger openings (30-40 μm in diameter) in the endothelium to allow red and white blood cells (7.5μm - 25μm diameter) and various serum proteins to pass, a process that is aided by a discontinuous basal lamina. These capillaries lack pinocytotic vesicles and gaps may be present in cell junctions permitting leakage between endothelial cells. Sinusoid blood vessels are primarily located in the liver, spleen, bone marrow, lymph nodes, and adrenal gland.

The membrane in the capillary is only 1 cell thick and is squamous epithelium.

Physiology

The capillary wall is a one-layer endothelium that allows gas and lipophilic molecules to pass through without the need for special transport mechanisms. This transport mechanism allows bidirectional diffusion depending on osmotic gradients and is further explained by the Starling equation.

Capillary beds may control their blood flow via autoregulation. This allows an organ to maintain constant flow despite a change in central blood pressure. This is achieved by myogenic response and in the kidney by tubuloglomerular feedback. When blood pressure increases the arterioles that lead to the capillaries bed are stretched and subsequently constrict to counteract the increased tendency for high pressure to increase blood flow. In the lungs special mechanisms have been adapted to meet the needs of increased necessity of blood flow during exercise. When the heart rate increases and more blood must flow through the lungs capillaries are recruited and are also distended to make room for increased blood flow. This allows blood flow to increase while resistance decreases.

Capillary permeability can be increased by the release of certain cytokines, anaphylatoxins, or other mediators (such as leukotrienes, prostaglandins, histamine, bradykinin, etc.) highly influenced by the immune system.

The Starling equation defines the forces across a semipermeable membrane and allows calculation of the net flux:

$\ J_v = K_f ( [P_c - P_i] - \sigma[\pi_c - \pi_i] )$

where:

$( [P_c - P_i] - \sigma[\pi_c - \pi_i] )$ is the net driving force,
$K_f$ is the proportionality constant, and
$J_v$ is the net fluid movement between compartments.

By convention, outward force is defined as positive, and inward force is defined as negative. The solution to the equation is known as the net filtration or net fluid movement (J_v). If positive, fluid will tend to leave the capillary (filtration). If negative, fluid will tend to enter the capillary (absorption). This equation has a number of important physiologic implications, especially when pathologic processes grossly alter one or more of the variables.

The variables

According to Starling's equation, the movement of fluid depends on six variables:

Capillary hydrostatic pressure ( P_c )
Interstitial hydrostatic pressure ( P_i )
Capillary oncotic pressure ( π_z )
Interstitial oncotic pressure ( π_i )
Filtration coefficient ( K_f )
Reflection coefficient ( σ )

Note that oncotic pressure is not illustrated in the image.

History

Ibn al-Nafis theorized a "premonition of the capillary circulation in his assertion that the pulmonary vein receives what comes out of the pulmonary artery, this being the reason for the existence of perceptible passages between the two."^[4]

Marcello Malpighi was the first to observe and correctly describe capillaries when he discovered them in a frog's lung in 1661.^[5]

References

↑ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey: Prentice Hall. ISBN 0-13-981176-1.
↑ Histology at BU 22401lba
↑ Pavelka, Margit; Jürgen Roth (2005). Functional Ultrastructure: An Atlas of Tissue Biology and Pathology. Springer. p. 232.
↑ Dr. Paul Ghalioungui (1982), "The West denies Ibn Al Nafis's contribution to the discovery of the circulation", Symposium on Ibn al-Nafis, Second International Conference on Islamic Medicine: Islamic Medical Organization, Kuwait (cf. The West denies Ibn Al Nafis's contribution to the discovery of the circulation, Encyclopedia of Islamic World)
↑ John Cliff, Walter (1976). Blood Vessels. CUP Archives. p. 14.